Nodes represent molecular components (e.g. proteins, macromolecular assemblies, lipids or small molecules) and edges represent physical interaction or transcriptional regulatory relationships between components (see legend/colour-chart on webpage).

The representation of a transcriptional association is abstracted to indicate the relationship between two proteins, one of which is a transcription factor that trans-activates the expression of the gene encoding the other protein.

Mouse-over nodes for a description of the components. Click on nodes for detailed information about the components.


Re-sizing network map
The height and width of the network map may be specified up to a maximum of 39 and 36 inches respectively. To effect the change, users can select to 'Display Network (Complete)' or 'Display Network ('Backbone')'.


Display Network (Complete)
This displays query nodes (red) and all interaction partners associated with the query nodes (Figure 1). Solid edges represent molecular interactions. Dashed/dotted edges denote transcriptional associations.

Figure 1.


Display Network ('Backbone')
Query nodes (red) and only common interaction partners linking these nodes together are displayed. Interaction clusters consisting of a single query node and their interaction partners are excluded. Network in Figure 1 is abstracted (Figure 2).

Figure 2.


If you encounter problems viewing graphics:
Some graph viewing problems may arise due to local cache settings in browser. First, you may wish to go back one page by clicking the "Back" button, and then re-launch the graphical map. If this fails, try re-setting the cache:

For Internet Explorer (6.x):
-> Tools (in menu bar of browser)
-> Internet Options
-> Settings (in "Temporary Internet files" section)
-> select "Every visit to the page"
-> click OK

For Netscape (7.1):
-> Edit (in menu bar of browser)
-> Advanced
-> Cache
-> select "Every time I view the page"
-> click OK


If you encounter problems viewing SVG graphics:
Viewing enhanced graphical maps in SVG format requires installation of one of the following SVG plug-ins for the browser:

Adobe SVG Viewer (v3.02)
Corel SVG Viewer

Zooming in Adobe SVG viewer is limited to four levels whereas Corel SVG viewer offers unlimited zoom features but is far less stable at higher zoom levels. Hence, we recommend Adobe, particularly version 3.02. Adobe v3.03 is not compatible.