pSTIING

pSTIING (Protein, Signalling, Transcriptional Interactions & Inflammation Networks Gateway) is a publicly accessible knowledgebase about protein-protein, protein-lipid, protein-small molecules, ligand-receptor interactions, receptor-cell type information, transcriptional regulatory and signal transduction modules relevant to inflammation, cell migration and tumourigenesis. It integrates in-house curated information from the literature, biochemical experiments, functional assays and in vivo studies, with publicly available information from multiple and diverse sources including genomic/proteomic data (e.g. UniGene, RefSeq, HUGO, UniProt/Swiss-Prot/TrEMBL, PDB, InterPro, Pfam), biomolecular interaction data (e.g. BIND, MINT, MIPS, HPRD, Reactome, InAct), transcriptional regulatory elements (e.g. JASPAR, EPD, TRED), signalling modules (e.g. KEGG, STKE, Biocarta, AfCS), human diseases (e.g. OMIM, PathologyOutlines) across human, rat, mouse, fly, worm and yeast.

Access to the knowledgebase is via this site, allowing users to search the knowledgebase and to dynamically generate visual representations of protein-protein interactions and transcriptional regulatory networks. Signalling and transcriptional modules can also be displayed singly or in combination. This allow users to identify important ‘cross-talks' between signalling modules via connections with key components or ‘hubs'.

This knowledgebase will facilitate a 'systems-wide' understanding across many protein, signalling and transcriptional regulatory networks triggered by multiple environmental cues, and also serve as a platform for future efforts to computationally and mathematically model the system behaviour of inflammatory processes and tumourigenesis.

Developed by

Aylwin Ng, Borisas Bursteinas, Alice Gao, Ewan Mollison and Marketa Zvelebil (Bioinformatics & Systems Biology Group) with contributions from Anne Ridley's Cancer Cell Biology Group and Buzz Baum's Morphogenesis Group at the Ludwig Institute for Cancer Research, London (University College) Branch.

Please contact Aylwin Ng or Marketa Zvelebil if you have any enquiries or feedback about pSTIING.

Publication:

Aylwin Ng, Borisas Bursteinas, Qiong Gao, Ewan Mollison and Marketa Zvelebil (2006). pSTIING: a 'systems' approach towards integrating signalling pathways, interaction and transcriptional regulatory networks in inflammation and cancer. Nucleic Acids Research 34: D527-D534. [Article]