pSTIING (Protein, Signalling, Transcriptional Interactions & Inflammation Networks Gateway)
is a publicly accessible knowledgebase about protein-protein, protein-lipid, protein-small molecules,
ligand-receptor interactions, receptor-cell type information, transcriptional regulatory and signal
transduction modules relevant to inflammation, cell migration and tumourigenesis. It integrates in-house
curated information from the literature, biochemical experiments, functional assays and in vivo studies,
with publicly available information from multiple and diverse sources across human, rat, mouse, fly, worm and yeast.
Access to the knowledgebase is via this site, allowing users to
search the knowledgebase and to dynamically generate
visual representations of protein-protein interactions and transcriptional regulatory networks.
Signalling and transcriptional modules can also be displayed singly or in combination.
This allow users to identify important ‘cross-talks' between signalling modules via connections
with key components or ‘hubs'.
This knowledgebase will facilitate a 'systems-wide' understanding across many protein,
signalling and transcriptional regulatory networks triggered by multiple environmental cues, and
also serve as a platform for future efforts to computationally and mathematically model the system
behaviour of inflammatory processes and tumourigenesis.
Please cite:
Aylwin Ng, Borisas Bursteinas, Qiong Gao, Ewan Mollison and Marketa Zvelebil (2006).
pSTIING: a 'systems' approach towards integrating signalling pathways, interaction and transcriptional
regulatory networks in inflammation and cancer. Nucleic Acids Research 34: D527-D534.
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